Overview

  • Product name

    VU0119498, M1 muscarinic receptor agonist and pan mAChR M3, M5 PAM
  • Description

    M1 muscarinic receptor agonist and pan mAChR M3, M5 PAM
  • Biological description

    M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM). Neuroprotective agent. Active in vitro.
  • Purity

    > 99%
  • CAS Number

    79183-37-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bridges TM  et al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett 20:1972-5 (2010). Read more (PubMed: 20156687) »
  • Marlo JE  et al. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol 75:577-88 (2009). Read more (PubMed: 19047481) »
  • Bridges TM  et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem 52:3445-8 (2009). Read more (PubMed: 19438238) »

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