Overview

  • Product name

    VU0152100, M4 positive allosteric modulator
  • Description

    Potent and selective M4 positive allosteric modulator
  • Biological description

    Potent and selective M4 mAChr positive allosteric modulator (IC50 = 380 nM). Does not possess intrinsic agonist activity. Inhibits behavioural and neurochemical effects of cocaine. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    409351-28-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Dencker D  et al. An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine. Psychopharmacology (Berl) 224:277-87 (2012). Read more (PubMed: 22648127) »
  • Kennedy JP  et al. Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor. ChemMedChem 4:1600-7 (2009). Read more (PubMed: 19705385) »
  • Brady AE  et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther 327:941-53 (2008). Read more (PubMed: 18772318) »

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