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VU0155041 sodium salt, PAM for mGluR4 (ab120248)

  • Datasheet
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  • COA
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Functional Studies - VU0155041 sodium salt, PAM for mGluR<sub>4</sub> (ab120248)

    Key features and details

    • PAM for mGluR4; water soluble
    • Purity: > 98%
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      VU0155041 sodium salt, PAM for mGluR4
    • Description

      PAM for mGluR4; water soluble
    • Biological description

      Positive allosteric selective modulator at mGluR4 (EC50 values are 798 and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is water soluble and more potent. Shows limited blood-brain barrier permeability. Active in behavioural models of Parkinson's disease following icv injection.

      Also available in simple stock solutions (ab146686) - add 1 ml of water to get an exact, ready-to-use concentration.

    • Purity

      > 98%
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt
    • Molecular weight

      338.16
    • Molecular formula

      C14H14Cl2NNaO3
    • PubChem identifier

      52974247
    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM
    • Handling

      This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      [Na]OC(=O)C2CCCCC2C(=O)Nc1cc(Cl)cc(Cl)c1
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Amino Acids
      • Glutamate
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Glutamate Receptors
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Glutamate
      • mGlu
      • Group III
      • Allosteric modulators
      • Biochemicals
      • Research Area
      • Addiction
      • Glutamate
      • mGlu
      • Group III
      • Allosteric modulators
      • Biochemicals
      • Research Area
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      • Glutamate
      • mGlu
      • Group III
      • Allosteric modulators
      • Biochemicals
      • Research Area
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      • Glutamate
      • mGlu
      • Group III
      • Allosteric modulators
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Glutamate
      • mGlu
      • Group III
      • Allosteric modulators
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Glutamate
      • mGlu
      • Group III
      • Allosteric modulators
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Glutamate
      • mGlu
      • Group III
      • Allosteric modulators
      • Biochemicals
      • Research Area
      • Stroke
      • Glutamate
      • mGlu
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    Associated products

    • Related Products

      • PHCCC, allosteric potentiator at mGlu4 (ab120043)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab120248 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies
    Use at an assay dependent concentration.
    Notes
    Functional Studies
    Use at an assay dependent concentration.

    Images

    • Functional Studies - VU0155041 sodium salt, PAM for mGluR<sub>4</sub> (ab120248)
      Functional Studies - VU0155041 sodium salt, PAM for mGluR4 (ab120248)

      SKNSH cells were incubated at 37°C for 30 minutes with vehicle control (0 μM) and different concentrations of VU0155041 sodium salt (ab120248). Increased expression of Gli1 (ab49314) in SKNSH cells correlates with an decrease in VU0155041 sodium salt concentration, as described in literature.

      Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 30 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab49314 at 2.5 μg/ml and ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti- rabbit antibody conjugated to HRP (ab97051) at 1/10000 and visualised using ECL development solution.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
    • COA
  • References (0)

    Publishing research using ab120248? Please let us know so that we can cite the reference in this datasheet.

    ab120248 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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