Overview

  • Product name

    VU0155069, PLD1 inhibitor
  • Description

    Potent and selective PLD1 inhibitor
  • Biological description

    Potent and selective PLD1 inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration in cancer cell lines.
  • Purity

    > 98%
  • CAS Number

    1130067-06-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Tsai YR  et al. Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils. Naunyn Schmiedebergs Arch Pharmacol 386:507-19 (2013). Read more (PubMed: 23525454) »
  • Scott SA  et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol 5:108-17 (2009). Read more (PubMed: 19136975) »
  • Lewis JA  et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett 19:1916-20 (2009). Read more (PubMed: 19268584) »

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