Overview

  • Product name
    VUF8430 dihydrobromide, H4 receptor agonist
  • Description
    Potent and high affinity H4 receptor agonist
  • Biological description
    Potent and high affinity H4 receptor agonist (pKi = 7.5 and pEC50 = 7.3). Additionally shows activity at H3 receptors (pKi = 6.5).
  • CAS Number
    100130-32-3
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Lim HD  et al. Molecular determinants of ligand binding to H4R species variants. Mol Pharmacol 77:734-43 (2010). Read more (PubMed: 20103609) »
  • Lim HD  et al. Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430. Br J Pharmacol 157:34-43 (2009). Read more (PubMed: 19413569) »
  • Lim HD  et al. Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem 49:6650-1 (2006). Read more (PubMed: 17154494) »

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