Overview

  • Product name

    VX-702, p38 MAP kinase inhibitor
  • Description

    Potent, selective p38 MAP kinase inhibitor
  • Biological description

    Potent, selective p38 MAP kinase inhibitor (Kd values are 3.7 and 17 nM for p38α and p38β, respectively). Active in vitro and in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    479543-46-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Goldstein DM  et al. Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem 53:2345-53 (2010). Read more (PubMed: 19950901) »
  • Kuliopulos A  et al. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation. Thromb Haemost 92:1387-93 (2004). Read more (PubMed: 15583748) »

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