VX-745, p38 alpha MAPK inhibitor (ab230367)

Overview

  • Product name

    VX-745, p38 alpha MAPK inhibitor
  • Description

    Potent, selective p38 alpha MAPK inhibitor
  • Alternative names

    • Neflamapimod
  • Biological description

    Potent, selective p38 alpha MAPK inhibitor (IC50 = 10 nM), with 20-fold selectivity over p38 beta and 1000-fold selectivity over closely related kinases, ERK1 and JNK1-3.

  • CAS Number

    209410-46-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one

  • Molecular weight

    436.26
  • Molecular formula

    C19H9Cl2F2N3OS
  • PubChem identifier

    3038525
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • Solubility overview

    VX-745 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2). We do not recommend storing the aqueous solution for more than one day.

  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    ClC1=C(C2=C(C=CC(SC3=CC=C(F)C=C3F)=N4)N4C=NC2=O)C(Cl)=CC=C1
  • Source

    Synthetic

References

This product has been referenced in:

  • Duffy JP  et al. The Discovery of VX-745: A Novel and Selective p38a Kinase Inhibitor. ACS Med Chem Lett 2:758-63 (2011). Read more (PubMed: 24900264) »
  • Goldstein DM  et al. Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem 53:2345-53 (2010). Read more (PubMed: 19950901) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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