Overview

  • Product name

    Anti-WAC antibody - C-terminal
    See all WAC primary antibodies
  • Description

    Rabbit polyclonal to WAC - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment within Human WAC (C terminal). The exact sequence is proprietary.
    Database link: Q9BTA9

  • Positive control

    • WB: HepG2 whole cell extract. IHC-P: Mouse testis tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.025% Proclin
    Constituents: PBS, 1% BSA, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab229574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 71 kDa.

Target

  • Function

    Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage.
  • Sequence similarities

    Contains 1 WW domain.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues.
  • Cellular localization

    Nucleus speckle. Nucleus. In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1110067P07Rik antibody
    • BA48B24 antibody
    • BA48B24.1 antibody
    • BM 016 antibody
    • FLJ31290 antibody
    • KIAA1844 antibody
    • MGC10753 antibody
    • OTTHUMP00000019380 antibody
    • OTTHUMP00000019382 antibody
    • PRO1741 antibody
    • wac antibody
    • WAC_HUMAN antibody
    • WW domain containing adapter protein with coiled coil antibody
    • WW domain containing adaptor with coiled coil antibody
    • WW domain-containing adapter protein with coiled-coil antibody
    • Wwp4 antibody
    see all

Images

  • Paraffin-embedded mouse testis tissue stained for WAC using ab229574 at 1/1000 dilution in immunohistochemical analysis

  • Anti-WAC antibody - C-terminal (ab229574) at 1/500 dilution + HepG2 (human liver hepatocellular carcinoma cell line) while cell extract at 30 µg

    Predicted band size: 71 kDa



    7.5% SDS PAGE gel.

References

ab229574 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab229574.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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