Overview

  • Product name

    Warfarin, Vitamin K epoxide reductase inhibitor
  • Description

    Vitamin K epoxide reductase inhibitor
  • Biological description

    Vitamin K epoxide reductase inhibitor. Synthetic derivative of coumarin. Inhibitor of
    CYP 2C9 when probed with diclofenac (IC50 = 21 μM). Anticoagulant effects. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    81-81-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one
  • Molecular weight

    308.33
  • Molecular formula

    C19H16O4
  • PubChem identifier

    54678486
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Beazley KE  et al. Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein. J Biol Chem 288:2632-40 (2013). Read more (PubMed: 23223575) »
  • Barone LM  et al. Differential effects of warfarin on mRNA levels of developmentally regulated vitamin K dependent proteins, osteocalcin, and matrix GLA protein in vitro. J Cell Physiol 160:255-64 (1994). Read more (PubMed: 8040186) »
  • Mukharji I & Silverman RB Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone. Proc Natl Acad Sci U S A 82:2713-7 (1985). Read more (PubMed: 3857611) »

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