Anti-WASF2/WAVE2 antibody (ab219812)

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Overview

  • Product name

    Anti-WASF2/WAVE2 antibody
    See all WASF2/WAVE2 primary antibodies

  • Description

    Rabbit polyclonal to WASF2/WAVE2

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WB, IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat

  • Immunogen

    Synthetic peptide corresponding to Human WASF2/WAVE2 aa 125-174.
    Sequence:

    NTCDTP PPLNNLTPYR DDGKEALKFY TDPSYFFDLW KEKMLQDTKD IMKE


    Database link: Q9Y6W5

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • WB: K562 cell lysate. IHC-P: Human lung tissue.

  • General notes

     This product was previously labelled as WASF2

     

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 0.87% Sodium chloride, 49% PBS
  • Concentration information loading...

  • Purity

    Immunogen affinity purified

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Research areas

Applications

Our Abpromise guarantee covers the use of ab219812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 54 kDa.
IHC-P 1/50.

Target

  • Function

    Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

  • Tissue specificity

    Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.

  • Sequence similarities

    Belongs to the SCAR/WAVE family.
    Contains 1 WH2 domain.

  • Domain

    Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.

  • Cellular localization

    Cytoplasm > cytoskeleton. Cell projection > lamellipodium. At the interface between the lamellipodial actin meshwork and the membrane.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • DICTYOSTELIUM antibody
    • dJ393P12.2 antibody
    • IMD2 antibody
    • Protein WAVE-2 antibody
    • Putative Wiskott Aldrich syndrome protein family member 4 antibody
    • SCAR 2 antibody
    • SCAR antibody
    • SCAR2 antibody
    • Suppressor of cyclic-AMP receptor (WASP family) antibody
    • Verprolin homology domain-containing protein 2 antibody
    • WASF2 antibody
    • WASF2_HUMAN antibody
    • WASF4 antibody
    • WASP family protein member 2 antibody
    • WASP family protein member 4 antibody
    • WASP family Verprolin homologous protein 2 antibody
    • WASP-family protein member 2 antibody
    • WAVE 2 antibody
    • WAVE2 antibody
    • Wiskott-Aldrich syndrome protein family member 2 antibody
    • Wiskott-Aldrich syndrome protein family verprolin-homologous protein antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WASF2/WAVE2 antibody (ab219812)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WASF2/WAVE2 antibody (ab219812)

    Immunohistochemical analysis of formalin-fixed paraffin-embedded human lung tissue sections labeling WASF2/WAVE2 with ab219812 at a 1/50 dilution.

  • Western blot - Anti-WASF2/WAVE2 antibody (ab219812)
    Western blot - Anti-WASF2/WAVE2 antibody (ab219812)
    Anti-WASF2/WAVE2 antibody (ab219812) at 1/500 dilution + K562 cell lysate

    Predicted band size: 54 kDa

References

ab219812 has not yet been referenced specifically in any publications.

Publishing research using ab219812? Please let us know so that we can cite the reference in this datasheet.

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