Overview

  • Product name

  • Description

    Rabbit polyclonal to WBP11
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Zebrafish
  • Immunogen

    Recombinant fragment corresponding to Human WBP11 aa 565-590 (internal sequence).
    Sequence:

    KPQITNPKAEITRFVPTALRVRRENK


    Database link: Q9Y2W2

  • Positive control

    • Human heart muscle tissue, U-2 OS cell line

Properties

Applications

Our Abpromise guarantee covers the use of ab204361 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100

Target

  • Function

    Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.
  • Tissue specificity

    Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung.
  • Cellular localization

    Nucleus. Cytoplasm. Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp779M1063 antibody
    • MGC94547 antibody
    • Npw38 binding protein antibody
    • Npw38 binding protein NpwBP antibody
    • Npw38-binding protein antibody
    • NpwBP antibody
    • PPP1R165 antibody
    • Protein phosphatase 1 regulatory subunit 165 antibody
    • SH3 domain binding protein SNP70 antibody
    • SH3 domain-binding protein SNP70 antibody
    • SIPP1 antibody
    • SNP70 antibody
    • Splicing factor PQBP1 and PP1 interacting antibody
    • Splicing factor that interacts with PQBP 1 and PP1 antibody
    • Splicing factor that interacts with PQBP-1 and PP1 antibody
    • WBP 11 antibody
    • WBP-11 antibody
    • Wbp11 antibody
    • WBP11_HUMAN antibody
    • WW domain binding protein 11 antibody
    • WW domain-binding protein 11 antibody
    see all

Images

  • Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2 OS cells labeling WBP11 with ab204361 at 4 µg/ml.

  • Immunohistochemical analysis of paraffin-embedded Human heart muscle tissue labeling WBP11 with ab204361 at 1/200 dilution.

References

ab204361 has not yet been referenced specifically in any publications.

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