Overview

  • Product name
  • Description
    Rabbit polyclonal to WDR11
  • Host species
    Rabbit
  • Tested applications
    Suitable for: Flow Cyt, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human WDR11 aa 551-580 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary. (NP_060587.8)
    Database link: Q9BZH6

  • Positive control
    • Mouse testis tissue lysate, 293 cells.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab175256 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/10 - 1/50.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

WB 1/100 - 1/500. Predicted molecular weight: 137 kDa.

Target

  • Relevance
    WDR11 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The WDR11 gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
  • Cellular localization
    Membrane; Single-pass membrane protein, Cytoplasmic and Nuclear
  • Database links
  • Alternative names
    • Bromodomain and WD repeat containing protein 2 antibody
    • Bromodomain and WD repeat domain containing 2 antibody
    • Bromodomain- and WD repeat-containing protein 2, formerly antibody
    • BRWD2 antibody
    • BRWD2, formerly antibody
    • DKFZp434L1715 antibody
    • DR11 antibody
    • FLJ42531 antibody
    • HH14 antibody
    • KIAA1351 antibody
    • WD repeat containing protein 11 antibody
    • WD repeat containing protein 15 antibody
    • WD repeat domain 11 antibody
    • WD repeat domain 15 antibody
    • WDR 11 antibody
    • WDR15 antibody
    see all

Images

  • Anti-WDR11 antibody (ab175256) at 1/100 dilution + mouse testis tissue lysate at 15 µg

    Predicted band size: 137 kDa

  • Flow cytometry analysis of 293 cells labeling WDR11 (green, right histogram), using ab175256 at a 1/10 dilution, and negative control cells (blue, left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

References

This product has been referenced in:
  • Kim YJ  et al. WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep 19:269-289 (2018). WB ; Mouse . Read more (PubMed: 29263200) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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