Overview

  • Product name
    Anti-WDR5 antibody [EPR11349(B)]
    See all WDR5 primary antibodies
  • Description
    Rabbit monoclonal [EPR11349(B)] to WDR5
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human WDR5. The exact sequence is proprietary.

  • Positive control
    • HeLa, A549 and Saos-2 cell lysates
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab156012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 36 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function
      Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
    • Sequence similarities
      Belongs to the WD repeat WDR5/wds family.
      Contains 7 WD repeats.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2410008O07Rik antibody
      • AA408785 antibody
      • AA960360 antibody
      • BIG 3 antibody
      • Big antibody
      • BIG3 antibody
      • BMP2 induced 3 kb gene protein antibody
      • BMP2 induced gene, 3-KB antibody
      • BMP2-induced 3-kb gene protein antibody
      • MGC114572 antibody
      • OTTHUMP00000162494 antibody
      • SWD 3 antibody
      • SWD3 antibody
      • SWD3 Set1c WD40 repeat protein homolog antibody
      • WD repeat containing protein 5 antibody
      • WD repeat domain 5 antibody
      • WD repeat protein 5 antibody
      • WD repeat-containing protein 5 antibody
      • WD repeat-containing protein BIG-3 antibody
      • WDR 5 antibody
      • Wdr5 antibody
      • WDR5_HUMAN antibody
      see all

    Images

    • All lanes : Anti-WDR5 antibody [EPR11349(B)] (ab156012) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : A549 cell lysate
      Lane 3 : Saos-2 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 36 kDa

    References

    This product has been referenced in:
    • Liu K  et al. Neuronal necrosis is regulated by a conserved chromatin-modifying cascade. Proc Natl Acad Sci U S A 111:13960-5 (2014). Read more (PubMed: 25201987) »
    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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