Overview

  • Product name
    Anti-WDR5 antibody - N-terminal
    See all WDR5 primary antibodies
  • Description
    Rabbit polyclonal to WDR5 - N-terminal
  • Host species
    Rabbit
  • Specificity
    ab189932 is predicted to not cross-react with other WDR family members.
  • Tested applications
    Suitable for: IHC-P, ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human WDR5 (N terminal). The peptide corresponds to 19 amino acids.
    Database link: P61964

  • Positive control
    • 293 cell lysate; Human brain cortex tissue; 293 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab189932 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 36 kDa.
ICC Use a concentration of 5 µg/ml.

Target

  • Function
    Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
  • Sequence similarities
    Belongs to the WD repeat WDR5/wds family.
    Contains 7 WD repeats.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2410008O07Rik antibody
    • AA408785 antibody
    • AA960360 antibody
    • BIG 3 antibody
    • Big antibody
    • BIG3 antibody
    • BMP2 induced 3 kb gene protein antibody
    • BMP2 induced gene, 3-KB antibody
    • BMP2-induced 3-kb gene protein antibody
    • MGC114572 antibody
    • OTTHUMP00000162494 antibody
    • SWD 3 antibody
    • SWD3 antibody
    • SWD3 Set1c WD40 repeat protein homolog antibody
    • WD repeat containing protein 5 antibody
    • WD repeat domain 5 antibody
    • WD repeat protein 5 antibody
    • WD repeat-containing protein 5 antibody
    • WD repeat-containing protein BIG-3 antibody
    • WDR 5 antibody
    • Wdr5 antibody
    • WDR5_HUMAN antibody
    see all

Images

  • All lanes : Anti-WDR5 antibody - N-terminal (ab189932) at 1 µg/ml

    Lane 1 : 293 cell lysate
    Lane 2 : 293 cell lysate with blocking peptide

    Predicted band size: 36 kDa

  • Immunocytochemistry analysis of 293 cells labeling WDR5 with ab189932 at 5 µg/ml.

  • Immunofluorescent analysis of 293 cells labeling WDR5 with ab189932 at 20 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cortex tissue labeling WDR5 with ab189932 at 5 µg/ml.

References

ab189932 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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