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Professor Gerald R Crabtree (Standford University, USA)
Professor Gerald Crabtree is based at Stanford University’s School of Medicine, where his laboratory studies the roles of chromatin in development and disease. The group has focused on ATP-dependent chromatin remodeling by the mSWI/SNF or BAF complex and its roles in cancer and neurodevelopment.
Professor Crabtree’s group, working with Stuart Schreiber, discovered the calcium-calcineurin-NFAT signaling pathway and demonstrated its role in a wide variety of developmental events. In the early 1990s, they also developed chemical inducers of proximity (CIPs), which are now widely used in experimental applications and cancer treatment.
Before Stanford University, Professor Crabtree established his own lab at the NIH in the early 1980s, where he used early bioinformatic methods to identify the remnants of ancient duplication events in the genome. He also demonstrated that one gene could produce different functional proteins by alternative splicing. Professor Crabtree grew up in West Virginia, USA, and has a medical degree from Temple University.