Chromatin remodeling: mechanistic insights from the genomics of human disease, Gerald Crabtree (Stanford University, USA)

Watch our on-demand Cambridge Epigenetics Club digital talk held on November 2, 2020.   


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Webinar objectives ​​

  • Understand how mammalian SWI/SNF or BAF complexes exist in hundreds of assemblies in mammalian cells
  • Review mechanistic insights from the genomics of human disease and new methods
  • Discuss how the frequency of BAF subunit mutations in neurodevelopment disorders such as autism is probably related to the functions of a neural-specific form of BAF complexes, nBAF.

Abcam is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.® Program. Interested in receiving P.A.C.E credit for this educational session? Request credit here!


Presenter​​

Professor Gerald R Crabtree (Standford University, USA)
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Professor Gerald Crabtree is based at Stanford University’s School of Medicine, where his laboratory studies the roles of chromatin in development and disease. The group has focused on ATP-dependent chromatin remodeling by the mSWI/SNF or BAF complex and its roles in cancer and neurodevelopment.

Professor Crabtree’s group, working with Stuart Schreiber, discovered the calcium-calcineurin-NFAT signaling pathway and demonstrated its role in a wide variety of developmental events. In the early 1990s, they also developed chemical inducers of proximity (CIPs), which are now widely used in experimental applications and cancer treatment.

Before Stanford University, Professor Crabtree established his own lab at the NIH in the early 1980s, where he used early bioinformatic methods to identify the remnants of ancient duplication events in the genome. He also demonstrated that one gene could produce different functional proteins by alternative splicing. Professor Crabtree grew up in West Virginia, USA, and has a medical degree from Temple University.

   Professor Gerald Crabtree is based at Stanford University’s School of Medicine, where his laboratory studies the roles of chromatin in development and disease. The group has focused on ATP-dependent chromatin remodeling by the mSWI/SNF or BAF complex and its roles in cancer and neurodevelopment.<br><br>Professor Crabtree’s group, working with Stuart Schreiber, discovered the calcium-calcineurin-NFAT signaling pathway and demonstrated its role in a wide variety of developmental events. In the early 1990s, they also developed chemical inducers of proximity (CIPs), which are now widely used in experimental applications and cancer treatment.<br><br>Before
 Stanford University, Professor Crabtree established his own lab at the NIH in the early 1980s, where he used early bioinformatic methods to identify the remnants of ancient duplication events in the genome. He also demonstrated that one gene could produce different functional proteins by alternative splicing. Professor Crabtree grew up in West Virginia, USA, and has a medical degree from Temple University.