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In this quick 30 minute presentation Dori will cover the following objectives:
About the Presenter:
Dorothy (Dori) Schafer received her bachelor’s degree in Neuroscience from Mount Holyoke College in 2001 and her Ph.D. in Biomedical Science from the University of Connecticut Health Center in 2008. She then began her postdoctoral training at Boston Children’s Hospital/Harvard Medical School in Dr. Beth Stevens’ laboratory. Here, she made the discovery that microglia, the resident CNS macrophages, sculpt neural circuits in the developing brain by engulfing a subset of less active synapses.
Dr. Schafer joined UMass Medical School in 2015 as an Assistant Professor in the Department of Neurobiology where she was a recipient of a NIH R00 Pathway to Independence Award (NIMH), Charles H. Hood Child Research Award, and NARSAD Young Investigator Grant. She later joined the Brudnik Neuropsychiatric Research Institute at UMass in 2018. Dr. Schafer is considered a leader in the field studying microglial function within neural circuits. Her earlier postdoctoral work showing microglia engulf and eliminate synapses via the classical complement cascade has served as a foundation for the field to understand new roles for microglia in regulating synaptic connectivity in health and disease. Her laboratory utilize a combination of cutting-edge molecular genetic approaches and imaging to uncover novel roles for microglia in modulating neural circuit structure and function in health and in neuroinflammatory diseases of the brain.
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