Rising Challenges in Immunology: Infectious and Autoimmune Diseases

Description:

With the COVID-19 pandemic and the increasing incidence of autoimmune disorders worldwide, research into basic and translational immunology is as vital as ever.

Watch this series of on-demand sessions dedicated to the latest breakthroughs in immunology, focusing on pressing challenges in respiratory infections (with an emphasis on COVID-19),  autoimmune diseases, immunometabolism and immunobiology, including immunometabolism, stromal and mucosal immunology. Gain insights into approaches impacting the field with talks from thought leaders across industry and academia.

On-demand sessions:​

• The evolving COVID-19 landscape: from fundamentals to new therapeutics
• Immunometabolism: fundamentals to prospective new therapies
• Autoimmune diseases: interplay between the innate and adaptive immune systems
• Autoimmune diseases: New perspectives on tolerance and mucosal immunology
• Spotlight on immunobiology: emerging trends and hot topics
  ​​

The evolving COVID-19 landscape: from fundamentals to new therapeutics

Webinar objectives

• Investigate the host response in patients with COVID-19 with differing outcomes
• Review Systems Serology’s novel approach to determining antibody function
• Demonstrate combined BCR sequencing and PhIP-Seq for parallel antibody & epitope discovery

​Speakers

• Galit Alter, Harvard Medical School, USA
  • Using Systems Serology to define correlates of immunity to SARS-CoV-2
  • Time stamp: 00:07:40
• Jake Galson, Alchemab Therapeutics, UK
  • Deep sequencing of patient BCRs for rapid COVID-19 mAb discovery
  • Time stamp: 00:36:04 
• Zeev Gechtman, Abcam, USA
  • Immune-response and cytokine storm in COVID-19
  • Time stamp: 00:59:00
• Julian Hiscox, University of Liverpool, UK
  • Analysis of SARS-CoV-2 in clinical samples and post-mortem tissue and what this tells us about COVID-19 in severe cases
  • Time stamp: 1:13:50
• Paul Kellam, Kymab, UK
  • Vaccines and monoclonal antibodies to SARS-CoV-2
  • Time stamp: 1:39:12 

Moderator

• Kovilen Sawmynaden, LifeArc, UK
  

Immunometabolism: fundamentals to prospective new therapies

Webinar objectives

• Discuss fundamental targeting of metabolic processes
• Describe metabolic control of inflammation
• Discuss mitochondrial metabolism and cancer immunity

​Speakers

• Jonathan Powell, Calico, USA
  • Some T effector cells just GOT1 it (and some don’t)
  • Time stamp: 00:07:26
• Remsha Afzal, Royal College of Surgeons in Ireland, Ireland
  • Mitochondrial Arginase-2 regulates IL-10 mediated metabolic reprogramming in inflammatory macrophage
  • Time stamp: 00:40:38
• Megan Hanlon, Trinity College Dublin, Ireland
  • Distinct metabolic myeloid profiles in Rheumatoid Arthritis
  • Time stamp: 00:57:09
• Ana Domingos, University of Oxford, UK
  • Sympathetic Neuroimmunometabolism
  • Time stamp: 01:19:52

Moderators

• Luke O'Neill, Trinity College Dublin, Ireland
• Evanna Mills, Harvard Medical School/Dana-Farber Cancer Institute, USA
• Mike Murphy, University of Cambridge, UK 
  

Autoimmune diseases: Interplay between the innate and adaptive immune systems

Webinar objectives​

• Uncover the role of T-cell immunoglobulin in intestinal homeostasis
• Review how the SLC15A4/TASL complex controls TLR7-9-induced IRF5 activation
• Discuss the role of the complosome in the regulation of T cell metabolism

Speakers

• Claudia Kemper, NIH, USA
  • ​Unexpected roles for the complosome in immune cell activities
  • Time stamp: 00:05:59 
• Manuele Rebsamen, University of Lausanne, Switzerland
  • New players in nucleic acid sensing and autoimmunity: the SLC15A4/TASL complex controls TLR-induced IRF5 activation
  • Time stamp: 00:33:00
• Janneke Samsom, Erasmus Medical Centre, The Netherlands
  • Unravelling the role of T-cell immunoglobulin and ITIM domain+ (TIGIT+) expressing CD4+ T cells in intestinal homeostasis
  • Time stamp: 00:58:32 
• Deborah Moore-Lai, Abcam, USA
  • Proteins and reagents for autoimmune diseases
  • Time stamp: 1:30:23 

Moderator

• Steven Ziegler, Benaroya Research Institute, USA
  ​

Autoimmune diseases: New perspectives on tolerance and mucosal immunology

Webinar objectives​

• Discuss the epithelial barrier hypothesis for the development of allergic and autoimmune diseases
• Review how cryptosporidium colonization can affect immune responses away from the site of infection
• Describe the differentiation of mucosal innate lymphoid cells in inflammatory bowel disease

Speakers

• Cezmi Akdis, Swiss Institute of Allergy and Asthma Research, Switzerland
  • Epithelial Barrier Hypothesis for the development of allergic and autoimmune diseases
  • Time stamp: 00:06:51
• Chyi-Song Hsieh, Washington University, USA
  • Discovery of a Th1 inducing Commensal Microbe in our colony - a model for the Hygiene Hypothesis?
  • Times tamp: 00:29:15 
• Jenny Mjösberg, Karolinska Institute, Sweden
  • ILC differentiation in inflammatory bowel disease
  • Time stamp: 00:53:33

Moderator

• Steven Ziegler, Benaroya Research Institute, USA
  ​

Spotlight on immunobiology: emerging trends and hot topics  

Webinar objectives​

• Analyze the role of Tregs in alveolar epithelial cell regeneration
• Review how Influenza and Salmonella induce Tfh and IL-12-independent early Th1 effector cells
• Discuss the use of intestinal organoids as tools for immunobiology research

Speakers

• Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
  • Lymphoid organ fibroblasts
  • Time stamp: 00:06:28 
• Mark Coles, University of Oxford, UK
  • Immunity by numbers - one cell at a time. Utilising the Human Cell Atlas to understand immunotherapies
  • Time stamp: 00:33:24 
• Joana Neves, King's College London, UK
  • Intestinal organoids as tools for immunobiology research
  • Time stamp: 00:59:24 
• Monica Sen, King's College London, UK
  • Defining the role of tissue-resident immune cells in alveolar epithelial cell regeneration
  • Time stamp: 1:23:15 
• Marc Jenkins, University of Minnesota, USA
  • Differentiation of antigen-specific Th1 cells during infection with a phagosomal pathogen
  • Time stamp: 1:44:35 

Moderator

• Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
  
  

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