Overview

  • Product name

    Wedelolactone, IkappaB kinase inhibitor
  • Description

    Selective and irreversible IκB kinase inhibitor
  • Biological description

    Selective and irreversible IκB kinase inhibitor. Inhibits osteoclastogenesis. Suppresses LPS-induced caspase 11 expression (IC50=35 µM). Shows hepatoprotective effects in vivo.
  • Purity

    > 98%
  • CAS Number

    524-12-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,8,9-Trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one
  • Molecular weight

    314.25
  • Molecular formula

    C16H10O7
  • PubChem identifier

    5281813
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O
  • Source

    Eclipta prostrasta L.

  • Research areas

References

This product has been referenced in:

  • Hsieh CJ  et al. Wedelolactone inhibits breast cancer-induced osteoclastogenesis by decreasing Akt/mTOR signaling. Int J Oncol : (2014). Read more (PubMed: 25421824) »
  • Kobori M  et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ 11:123-30 (2004). Read more (PubMed: 14526390) »
  • Singh B  et al. In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian J Physiol Pharmacol 45:435-41 (2001). Read more (PubMed: 11883149) »

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