Anti-WFS1 antibody (ab224767)
Key features and details
- Rabbit polyclonal to WFS1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-WFS1 antibody
See all WFS1 primary antibodies -
Description
Rabbit polyclonal to WFS1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human WFS1 aa 750 to the C-terminus.
Database link: O76024 -
Positive control
- IHC-P: Human heart muscle, Lung, Testis and Pancreas tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab224767 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Relevance
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome. -
Cellular localization
Endoplasmic reticulum; endoplasmic reticulum membrane; multipass membrane protein -
Database links
- Entrez Gene: 7466 Human
- Omim: 606201 Human
- SwissProt: O76024 Human
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Alternative names
- CTRCT41 antibody
- DFNA14 antibody
- DFNA38 antibody
see all
Images
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Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) analysis in human Heart muscle tissue labeling GUSB with ab224767 at 1/500 dilution.
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Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) analysis in human Lung tissue labeling GUSB with ab224767 at 1/500 dilution.
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Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) analysis in human Testis tissue labeling GUSB with ab224767 at 1/500 dilution.
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Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) analysis in human Pancreas tissue labeling GUSB with ab224767 at 1/500 dilution.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab224767 has not yet been referenced specifically in any publications.