• Product name
  • Description
    Rabbit polyclonal to WIPF1
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 400 - 500 of Human WIPF1.

  • Positive control
    • This antibody gave a positive signal in Jurkat whole cell lysate as well as the following Human tissue lysates: Tonsil; Platelet; Spleen; Placenta; Colon; Thymus.



Our Abpromise guarantee covers the use of ab98176 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).


  • Function
    May have direct activity on the actin cytoskeleton. Induces actin polymerization and redistribution. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
  • Tissue specificity
    Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.
  • Sequence similarities
    Belongs to the verprolin family.
    Contains 1 WH2 domain.
  • Domain
    Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site.
  • Cellular localization
    Cytoplasmic vesicle. Cytoplasm > cytoskeleton. Vesicle surfaces and along actin tails. Co-localized with actin stress fibers. When co-expressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI115543 antibody
    • D2Ertd120e antibody
    • MGC111041 antibody
    • Protein PRPL-2 antibody
    • PRPL 2 antibody
    • PRPL-2 protein antibody
    • WAS/WASL interacting protein family member 1 antibody
    • WAS/WASL-interacting protein family member 1 antibody
    • WAS2 antibody
    • WASP-interacting protein antibody
    • WASPIP antibody
    • WIP antibody
    • Wipf1 antibody
    • WIPF1_HUMAN antibody
    • Wiskott-Aldrich syndrome protein interacting protein antibody
    • Wiskott-Aldrich syndrome protein-interacting protein antibody
    see all


  • All lanes : Anti-WIPF1 antibody (ab98176) at 1 µg/ml

    Lane 1 : Tonsil (Human) Tissue Lysate
    Lane 2 : Platelet (Human) Whole Cell Lysate
    Lane 3 : Human spleen tissue lysate - total protein (ab29699)
    Lane 4 : Human placenta tissue lysate - total protein (ab29745)
    Lane 5 : Human colon tissue lysate - total protein (ab30051)
    Lane 6 : Human thymus tissue lysate - total protein (ab30146)
    Lane 7 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 51 kDa
    Observed band size: 51 kDa

    Exposure time: 2 minutes


ab98176 has not yet been referenced specifically in any publications.

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