Overview

  • Product name

  • Description

    Rabbit polyclonal to WIPI1
  • Host species

    Rabbit
  • Specificity

    At least two isoforms of WIPI1 are known to exist; ab139722 will detect both isoforms.
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to 17 amino acid residues near the carboxy terminus of Human WIPI1 (NP_060453).

  • Positive control

    • Rat colon tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab139722 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 49 kDa.
ICC/IF Use a concentration of 20 µg/ml.

Target

  • Function

    May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
  • Tissue specificity

    Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues.
  • Sequence similarities

    Belongs to the WD repeat SVP1 family.
    Contains 3 WD repeats.
  • Cellular localization

    Golgi apparatus > trans-Golgi network. Endosome. Cytoplasmic vesicle > clathrin-coated vesicle. Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles.
  • Information by UniProt
  • Database links

  • Alternative names

    • ATG 18 antibody
    • ATG18 antibody
    • Atg18 protein homolog antibody
    • ATG18A antibody
    • FLJ10055 antibody
    • WD repeat domain phosphoinositide interacting 1 antibody
    • WD repeat domain phosphoinositide interacting protein 1 antibody
    • WD repeat domain phosphoinositide-interacting protein 1 antibody
    • WD40 repeat protein interacting with phosphoinositides of 49 kDa antibody
    • WD40 repeat protein interacting with phosphoInositides of 49kDa antibody
    • WIPI 1 alpha antibody
    • WIPI 1 antibody
    • WIPI 49 antibody
    • WIPI 49 kDa antibody
    • WIPI-1 antibody
    • wipi1 antibody
    • WIPI1_HUMAN antibody
    • WIPI49 antibody
    see all

Images

  • Immunofluorescence of WIPI1 in Human colon tissue with ab139722 at 20 ug/mL.
  • Lane 1 : Anti-WIPI1 antibody (ab139722) at 1 µg/ml
    Lane 2 : Anti-WIPI1 antibody (ab139722) at 2 µg/ml

    Lane 1 : Rat colon tissue lysate
    Lane 2 : Rat colon tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 49 kDa

References

ab139722 has not yet been referenced specifically in any publications.

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