Wiskostatin, N-WASP inhibitor (ab141085)
Key features and details
- Selective N-WASP inhibitor
- CAS Number: 253449-04-6
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Wiskostatin, N-WASP inhibitor -
Description
Selective N-WASP inhibitor -
Biological description
Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton.
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Purity
> 99% -
CAS Number
253449-04-6 -
Chemical structure
Properties
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Chemical name
3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol -
Molecular weight
426.15 -
Molecular formula
C17H18Br2N2O -
PubChem identifier
2775510 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CC(O)Cn3c1ccc(Br)cc1c2cc(Br)ccc23 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Wiskostatin, N-WASP inhibitor (ab141085)2D chemical structure image of ab141085, Wiskostatin, N-WASP inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab141085 has been referenced in 2 publications.
- Soykan T et al. Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron 93:854-866.e4 (2017). PubMed: 28231467
- Baranov MV et al. Podosomes of dendritic cells facilitate antigen sampling. J Cell Sci 127:1052-64 (2014). PubMed: 24424029