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    wiskostatin-n-wasp-inhibitor-ab141085.pdf

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Wiskostatin, N-WASP inhibitor (ab141085)

  • Datasheet
  • SDS
  • COA
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Key features and details

  • Selective N-WASP inhibitor
  • CAS Number: 253449-04-6
  • Purity: > 99%
  • Soluble in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Wiskostatin, N-WASP inhibitor
  • Description

    Selective N-WASP inhibitor
  • Biological description

    Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton.

  • Purity

    > 99%
  • CAS Number

    253449-04-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
  • Molecular weight

    426.15
  • Molecular formula

    C17H18Br2N2O
  • PubChem identifier

    2775510
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)CC(O)Cn3c1ccc(Br)cc1c2cc(Br)ccc23
  • Source

    Synthetic

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Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (2)

Publishing research using ab141085? Please let us know so that we can cite the reference in this datasheet.

ab141085 has been referenced in 2 publications.

  • Soykan T  et al. Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron 93:854-866.e4 (2017). PubMed: 28231467
  • Baranov MV  et al. Podosomes of dendritic cells facilitate antigen sampling. J Cell Sci 127:1052-64 (2014). PubMed: 24424029

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