Wiskostatin, N-WASP inhibitor (ab141085)
- Datasheet
- References (1)
Overview
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Product name
Wiskostatin, N-WASP inhibitor -
Description
Selective N-WASP inhibitor -
Biological description
Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton. -
Purity
> 99% -
CAS Number
253449-04-6 -
Chemical structure
Properties
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Chemical name
3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol -
Molecular weight
426.15 -
Molecular formula
C17H18Br2N2O -
PubChem identifier
2775510 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CC(O)Cn3c1ccc(Br)cc1c2cc(Br)ccc23 -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Pfannes EK et al. Impact of the carbazole derivative wiskostatin on mechanical stability and dynamics of motile cells. J Muscle Res Cell Motil 33:95-106 (2012). Read more (PubMed: 22407517) »
- Guerriero CJ & Weisz OA N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am J Physiol Cell Physiol 292:C1562-6 (2007). Read more (PubMed: 17092993) »
- Peterson JR et al. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol 11:747-55 (2004). Read more (PubMed: 15235593) »
