Anti-Wnt4 antibody (ab169592)
- Datasheet
- References
- Protocols
Overview
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Product nameAnti-Wnt4 antibody
See all Wnt4 primary antibodies -
DescriptionMouse polyclonal to Wnt4
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Host speciesMouse
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Tested applicationsSuitable for: WBmore details
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Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Chicken, Xenopus laevis
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Immunogen
Full length protein, corresponding to amino acids 1-351 of Human Wnt4 (Accession number: NP_110388.2; UniProt ID: P56705).
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Positive control
- Wnt4 transfected 293T cell lysate.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
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Storage bufferpH: 7.20
Constituent: 99% PBS -
Concentration information loading... -
PurityProtein A purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab169592 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa. |
Target
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FunctionLigand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.
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Involvement in diseaseDefects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome) [MIM:277000]; also called Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls.
Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]; also known as SERKAL syndrome.
Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL) [MIM:158330]. -
Sequence similaritiesBelongs to the Wnt family.
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Cellular localizationSecreted > extracellular space > extracellular matrix.
- Information by UniProt
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Database links
- Entrez Gene: 54361 Human
- Entrez Gene: 22417 Mouse
- Entrez Gene: 84426 Rat
- Entrez Gene: 397706 Xenopus laevis
- Omim: 603490 Human
- SwissProt: P49337 Chicken
- SwissProt: P56705 Human
- SwissProt: P22724 Mouse
see all -
Alternative names
- MGC123964 antibody
- Protein Wnt-4 antibody
- RP23-246F18.1 antibody
see all
Images
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Western blot - Anti-Wnt4 antibody (ab169592)All lanes : Anti-Wnt4 antibody (ab169592) at 1 µg/ml
Lane 1 : Wnt4 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 15 µl per lane.
Secondary
All lanes : Goat anti-Mouse IgG HRP at 1/2500 dilution
Predicted band size: 39 kDa
Protocols
Datasheets and documents
References
ab169592 has not yet been referenced specifically in any publications.
