Overview

  • Product name

    Wogonoside, glycosides of wogonin
  • Description

    Glycosides of wogonin
  • Biological description

    Glycosides of wogonin (ab142471). Induces cell cycle arrest at G1 phase. Promotes differentiation. Shows antiproliferative and antiangiogenic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    51059-44-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(5-hydroxy-8-methoxy-4-oxo-2-phenylchromen-7-yl)-6-oxohexanoic acid
  • Molecular weight

    460.39
  • Molecular formula

    C22H20O11
  • PubChem identifier

    29927693
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C2C(=C(C=C1C(C=O)(C(C(C(C(=O)O)O)O)O)O)O)C(=O)C=C(O2)C3=CC=CC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Fong SY  et al. Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. J Pharm Biomed Anal 97C:9-23 (2014). Read more (PubMed: 24803030) »
  • Chen Y  et al. Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells. Blood 121:3682-91 (2013). Read more (PubMed: 23487022) »
  • Chen Y  et al. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Toxicology 259:10-7 (2009). Read more (PubMed: 19428938) »
  • Zhang K  et al. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. Cancer Sci 99:689-95 (2008). Read more (PubMed: 18377421) »

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