Overview

  • Product name

    WP1066 (DMSO solution), JAK/STAT3 inhibitor
  • Description

    Cell-permeable JAK/STAT3 inhibitor; AG 490 analog
  • Biological description

    JAK/STAT3 inhibitor (IC50 = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Blood-brain barrier permeable.

    Also available as a solid (ab141440).
  • Purity

    > 97%
  • CAS Number

    857064-38-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Tang YJ  et al. Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro. Genet Mol Res 14:2450-60 (2015). Read more (PubMed: 25867391) »
  • Lee HT  et al. Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells. Oncotarget 6:10016-29 (2015). Read more (PubMed: 25881542) »
  • Lu K  et al. The STAT3 inhibitor WP1066 synergizes with vorinostat to induce apoptosis of mantle cell lymphoma cells. Biochem Biophys Res Commun 464:292-8 (2015). Read more (PubMed: 26116769) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146607.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up