Overview

  • Product name

    WP1066, JAK/STAT3 inhibitor
  • Description

    JAK/STAT3 inhibitor; AG 490 analog
  • Biological description

    JAK/STAT3 inhibitor (IC50 = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Cell-permeable. Blood-brain barrier permeable.
  • Purity

    > 97%
  • CAS Number

    857064-38-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Horiguchi A  et al. STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma. Br J Cancer 102:1592-9 (2010). Read more (PubMed: 20461084) »
  • Verstovsek S  et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res 14:788-96 (2008). Read more (PubMed: 18245540) »
  • Iwamaru A  et al. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 26:2435-44 (2007). Read more (PubMed: 17043651) »

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