Overview

  • Product name

    WRW4, FPRL1 antagonist
  • Description

    Selective FPRL1 antagonist
  • Biological description

    Selective FPRL1 antagonist. Inhibits binding of agonist WKYMVm to formyl peptide receptor-like 1 (FPRL1). Inhibits intracellular calcium release, kinase activation and chemotactic cell migration towards WKYMVm.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1104.30
  • Molecular formula

    C61H65N15O6
  • Sequence

    WRWWWW
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Stock solution of up to 1mM should be done in DDW. Further dilutions can be done in any physiological buffer.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cattaneo F  et al. NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells. Free Radic Biol Med 51:1126-36 (2011). Read more (PubMed: 21708247) »
  • Kim Y  et al. Pituitary adenylate cyclase-activating polypeptide 27 is a functional ligand for formyl peptide receptor-like 1. J Immunol 176:2969-75 (2006). Read more (PubMed: 16493055) »
  • Bae YS  et al. Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol 173:607-14 (2004). Read more (PubMed: 15210823) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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