Overview

  • Product name

    WS 12, TRPM8 agonist
  • Description

    Potent, selective TRPM8 agonist
  • Biological description

    Potent, selective TRPM8 agonist (EC50 = 193 nM). Increases intracellular Ca2+ concentration. Reduces epidermal proliferation associated with barrier disruption. Shows cooling effects in vivo.
  • Purity

    > 98%
  • CAS Number

    68489-09-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
  • Molecular weight

    289.42
  • Molecular formula

    C18H27NO2
  • PubChem identifier

    11266244
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Nocchi L  et al. Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging. Aging Cell 13:540-50 (2014). Read more (PubMed: 24593692) »
  • Tsumura M  et al. Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts. PLoS One 8:e82233 (2013). Read more (PubMed: 24358160) »
  • Denda M  et al. Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis. Exp Dermatol 19:791-5 (2010). Read more (PubMed: 20636355) »

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