Overview

  • Product name

    WY 14643, PPARalpha agonist
  • Description

    Selective PPARα agonist
  • Biological description

    Selective PPARα agonist (EC50 values are 0.63, 32 and >100 μM at PPARα, PPARγ and PPARδ receptors respectively). Able to reduce inflammatory responses in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    50892-23-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
  • Molecular weight

    323.80
  • Molecular formula

    C14H14ClN3O2S
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cc2cccc(Nc1cc(Cl)nc(SCC(=O)O)n1)c2C
  • Source

    Synthetic

References

This product has been referenced in:

  • Willson TM  et al. The PPARs: from orphan receptors to drug discovery. J Med Chem 43:527-50 (2000). Read more (PubMed: 10691680) »
  • Bishop-Bailey D Peroxisome proliferator-activated receptors in the cardiovascular system. Br J Pharmacol 129:823-34 (2000). Read more (PubMed: 10696077) »
  • Forman BM  et al. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A 94:4312-7 (1997). Read more (PubMed: 9113986) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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