Key features and details
- Selective PPARα agonist
- CAS Number: 50892-23-4
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameWY 14643, PPARalpha agonist
DescriptionSelective PPARα agonist
Selective PPARα agonist (EC50 values are 0.63, 32 and >100 μM at PPARα, PPARγ and PPARδ receptors respectively). Able to reduce inflammatory responses in vivo and in vitro.
Chemical name2-[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141142 has been referenced in 2 publications.
- Huang Y et al. Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPARa pathway. Appl Physiol Nutr Metab 45:227-239 (2020). PubMed: 31173696
- Luo R et al. Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. Autophagy 16:52-69 (2020). PubMed: 30898012