Overview

  • Product name
    WZ 4003, NUAK kinase inhibitor
  • Description
    Potent, selective NUAK kinase inhibitor
  • Biological description
    Potent, selective NUAK kinase inhibitor (IC50 values are 20 and 100 nM for NUAK1 and NUAK2, respectively). Impairs invasive potential of U2OS cells. Shows antiproliferative effects.
  • Purity
    > 98%
  • CAS Number
    1214265-58-3
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide
  • Molecular weight
    497.00
  • Molecular formula
    C25H29ClN6O3
  • PubChem identifier
    72200024
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CN1CCN(CC1)c4cc(OC)c(Nc3nc(Oc2cccc(NC(=O)CC)c2)c(Cl)cn3)cc4
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Banerjee S  et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J 457:215-25 (2014). Read more (PubMed: 24171924) »
  • Banerjee S  et al. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1ßMYPT1 phosphatase complex and the SCFßTrCP E3 ubiquitin ligase. Biochem J 461:233-45 (2014). Read more (PubMed: 24785407) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144820.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up