Overview

  • Product name

    Xanomeline oxalate, M1 muscarinic acetylcholine receptor agonist
  • Description

    Functionally preferring M1 muscarinic acetylcholine receptor agonist
  • Alternative names

    • LY-246708
  • Biological description

    Functionally preferring M1 muscarinic acetylcholine receptor agonist (pKi values are 7.1 (M1), 6.9 (M2), 7.4 (M3), 7.7 (M4) and 7.4 (M5)). Able to cross blood-brain barrier. Displays antipsychotic activity.
  • Purity

    > 99%
  • CAS Number

    141064-23-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate
  • Molecular weight

    371.45
  • Molecular formula

    C14H23N3OS.C2H2O4
  • PubChem identifier

    18920248
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM and ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)C(=O)O.CN1CCC=C(C1)c2nsnc2OCCCCCC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Dencker D  et al. Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline. J Neurosci 31:5905-8 (2011). Read more (PubMed: 21508215) »
  • Watson J  et al. Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors. Br J Pharmacol 125:1413-20 (1998). Read more (PubMed: 9884068) »
  • Shannon HE  et al. Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors. J Pharmacol Exp Ther 269:271-81 (1994). Read more (PubMed: 7909557) »

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