Anti-XBP1 antibody (ab85546)
Key features and details
- Goat polyclonal to XBP1
- Suitable for: ELISA, IHC-P
- Reacts with: Mouse, Dog, Human
- Isotype: IgG
Overview
-
Product name
Anti-XBP1 antibody
See all XBP1 primary antibodies -
Description
Goat polyclonal to XBP1 -
Host species
Goat -
Tested applications
Suitable for: ELISA, IHC-Pmore details
Unsuitable for: WB -
Species reactivity
Reacts with: Mouse, Dog, Human
Predicted to work with: Chimpanzee, Gorilla -
Immunogen
Synthetic peptide:
NHSWEDTFANELFPQ
by a Cysteine residue linker, corresponding to C terminal amino acids 358-372 of Human XBP1 isoform 2 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab85546 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ELISA |
Use at an assay dependent concentration.
|
|
IHC-P | (4) |
Use a concentration of 5 µg/ml.
|
Notes |
---|
ELISA
Use at an assay dependent concentration. |
IHC-P
Use a concentration of 5 µg/ml. |
Target
-
Function
Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. -
Involvement in disease
Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. -
Sequence similarities
Belongs to the bZIP family.
Contains 1 bZIP domain. -
Cellular localization
Nucleus. - Information by UniProt
-
Database links
- Entrez Gene: 7494 Human
- Entrez Gene: 22433 Mouse
- Omim: 194355 Human
- SwissProt: P17861 Human
- SwissProt: O35426 Mouse
- Unigene: 437638 Human
- Unigene: 469937 Mouse
-
Alternative names
- Tax responsive element binding protein 5 antibody
- Tax-responsive element-binding protein 5 antibody
- TREB5 antibody
see all
Images
Protocols
Datasheets and documents
-
Datasheet download
References (4)
ab85546 has been referenced in 4 publications.
- Obert DP et al. ER stress preconditioning ameliorates liver damage after hemorrhagic shock and reperfusion. Exp Ther Med 21:248 (2021). PubMed: 33603856
- Pavlovic N et al. Inhibiting IRE1a-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma. Elife 9:N/A (2020). PubMed: 33103995
- Wolpert A et al. Hepatic topographical changes of endoplasmic reticulum stress and unfolded protein response signaling after hemorrhagic shock and reperfusion. J Surg Res 231:278-289 (2018). PubMed: 30278941
- Piret SE et al. A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress. Dis Model Mech 10:773-786 (2017). IHC-P ; Mouse . PubMed: 28325753