Xestospongin C, IP3 receptor antagonist (ab120914)

Submit a review Q&A (1)References (7)
Chemical Structure - Xestospongin C, IP<sub>3</sub> receptor antagonist (ab120914)

    Key features and details

    • Potent, selective, reversible IP3 receptor antagonist
    • CAS Number: 88903-69-9
    • Purity: > 90%
    • Soluble in DMSO to 2 mM and in ethanol to 2 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Xestospongin C, IP3 receptor antagonist

    • Description

      Potent, selective, reversible IP3 receptor antagonist

    • Alternative names

      • Araguspongine E
      • XeC

    • Biological description

      Potent, selective, reversible IP3 receptor antagonist (IC50 = 350 nM). Inhibits IP3-mediated Ca2+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca2+ and K+ channels at higher concentrations. Cell-permeable.

    • Purity

      > 90%

    • CAS Number

      88903-69-9

    • Chemical structure

      Chemical Structure

    Properties

    Associated products

      Images

      • Chemical Structure - Xestospongin C, IP<sub>3</sub> receptor antagonist (ab120914)
        Chemical Structure - Xestospongin C, IP3 receptor antagonist (ab120914)
        2D chemical structure image of ab120914, Xestospongin C, IP3 receptor antagonist

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      References (7)

      Publishing research using ab120914? Please let us know so that we can cite the reference in this datasheet.

      ab120914 has been referenced in 7 publications.

      • Wang J  et al. Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3. Biochem Pharmacol 174:113832 (2020). PubMed: 32006470
      • Chen T  et al. ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury. Neuroscience 416:268-280 (2019). PubMed: 31425734
      • Jiang C  et al. VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine. Neuropsychopharmacology 44:971-981 (2019). PubMed: 30504797
      • Shen Y  et al. Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions. Nat Commun 10:2924 (2019). PubMed: 31266950
      • James TD  et al. Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling. Elife 8:N/A (2019). PubMed: 31180325
      • Pick JE  et al. mGluR long-term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum. EMBO J 36:232-244 (2017). PubMed: 27856517
      • Fazal L  et al. Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death. Circ Res 120:645-657 (2017). PubMed: 28096195

      Customer reviews and Q&As

      Show All Reviews Q&A
      Submit a review Submit a question

      Question

      Can you tell me if your product is in clear glass or amber vials?

      Read More
      Answer

      We have some inventory of Xestospongin C in clear glass. We are currently in the process of changing from clear glass vials to amber vials for this product. Supplying Xestospongin C in amber vials is a precautionary measure as it appears that Xestospongin C’s sensitivity to light is based on long term studies (6+ months of exposure to direct light). Since the product is intended to be kept at – 20 C for long term storage primarily it will be in the freezer where it is dark, the customer could shield the vial from light when it is outside of the freezer if it is in a clear vial.

      Read More

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
      For licensing inquiries, please contact partnerships@abcam.com