Xestospongin C, IP3 receptor antagonist (ab120914)

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Overview

  • Product name

    Xestospongin C, IP3 receptor antagonist

  • Description

    Potent, selective, reversible IP3 receptor antagonist

  • Alternative names

    • Araguspongine E
    • XeC

  • Biological description

    Potent, selective, reversible IP3 receptor antagonist (IC50 = 350 nM). Inhibits IP3-mediated Ca2+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca2+ and K+ channels at higher concentrations. Cell-permeable.

  • Purity

    > 90%

  • CAS Number

    88903-69-9

  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Zhao Y  et al. Anesthetic-induced neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors. J Pharmacol Exp Ther 333:14-22 (2010). Read more (PubMed: 20086058) »
  • Oka T  et al. Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells. Br J Pharmacol 135:1959-66 (2002). Read more (PubMed: 11959799) »
  • Ozaki H  et al. Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. Br J Pharmacol 137:1207-12 (2002). Read more (PubMed: 12466229) »
See 1 Publication for this product

Publishing research using ab120914? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

Can you tell me if your product is in clear glass or amber vials?

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Answer

We have some inventory of Xestospongin C in clear glass. We are currently in the process of changing from clear glass vials to amber vials for this product. Supplying Xestospongin C in amber vials is a precautionary measure as it appears that Xestospongin C’s sensitivity to light is based on long term studies (6+ months of exposure to direct light). Since the product is intended to be kept at – 20 C for long term storage primarily it will be in the freezer where it is dark, the customer could shield the vial from light when it is outside of the freezer if it is in a clear vial.

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