Xestospongin C, IP3 receptor antagonist (ab120914)
Key features and details
- Potent, selective, reversible IP3 receptor antagonist
- CAS Number: 88903-69-9
- Purity: > 90%
- Soluble in DMSO to 2 mM and in ethanol to 2 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Xestospongin C, IP3 receptor antagonist -
Description
Potent, selective, reversible IP3 receptor antagonist -
Alternative names
- Araguspongine E
- XeC
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Purity
> 90% -
CAS Number
88903-69-9 -
Chemical structure
Properties
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Chemical name
(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine -
Molecular weight
446.72 -
Molecular formula
C28H50N2O2 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 2 mM and in ethanol to 2 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CCC[C@H]2CCCN3CCC(CCCCCCC4CCCN5CCC(CC1)O[C@H]45)O[C@H]23 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Xestospongin C, IP3 receptor antagonist (ab120914)2D chemical structure image of ab120914, Xestospongin C, IP3 receptor antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (9)
ab120914 has been referenced in 9 publications.
- Wang J et al. Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3. Biochem Pharmacol 174:113832 (2020). PubMed: 32006470
- Gupta K et al. Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel. Biomaterials 259:120283 (2020). PubMed: 32827796
- Luo R et al. Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats. FEBS J 286:4356-4373 (2019). PubMed: 31230413
- Chen T et al. ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury. Neuroscience 416:268-280 (2019). PubMed: 31425734
- Jiang C et al. VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine. Neuropsychopharmacology 44:971-981 (2019). PubMed: 30504797
- Shen Y et al. Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions. Nat Commun 10:2924 (2019). PubMed: 31266950
- James TD et al. Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling. Elife 8:N/A (2019). PubMed: 31180325
- Pick JE et al. mGluR long-term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum. EMBO J 36:232-244 (2017). PubMed: 27856517
- Fazal L et al. Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death. Circ Res 120:645-657 (2017). PubMed: 28096195