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    xestospongin-c-ip3-receptor-antagonist-ab120914.pdf

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Biochemicals Chemical Type Biochemicals
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Xestospongin C, IP3 receptor antagonist (ab120914)

  • Datasheet
  • SDS
Submit a review Q&A (1)References (11)

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Chemical Structure - Xestospongin C, IP<sub>3</sub> receptor antagonist (ab120914)

    Key features and details

    • Potent, selective, reversible IP3 receptor antagonist
    • CAS Number: 88903-69-9
    • Purity: > 90%
    • Soluble in DMSO to 2 mM and in ethanol to 2 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      Xestospongin C, IP3 receptor antagonist
    • Description

      Potent, selective, reversible IP3 receptor antagonist
    • Alternative names

      • Araguspongine E
      • XeC
    • Purity

      > 90%
    • CAS Number

      88903-69-9
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine
    • Molecular weight

      446.72
    • Molecular formula

      C28H50N2O2
    • Storage instructions

      Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
    • Solubility overview

      Soluble in DMSO to 2 mM and in ethanol to 2 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      C1CCC[C@H]2CCCN3CCC(CCCCCCC4CCCN5CCC(CC1)O[C@H]45)O[C@H]23
    • Source

      Synthetic

    • Research areas

      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Signaling
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia
      • Biochemicals
      • Research Area
      • Heart disease
      • Signaling
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Signaling
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Signaling
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Diabetes
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Diabetes
      • Signaling
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Heart disease
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Hypertension
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Hypertension
      • Signaling
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Obesity
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Obesity
      • Signaling
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Signaling
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Stroke
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Research Area
      • Stroke
      • Signaling
      • Ca2+ signaling
      • IP3 & ryanodine receptors
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Inositol triphosphate receptor
      • Antagonists
      • Biochemicals
      • Pharmacology
      • Signaling
      • Signal transduction
      • Inositol & cAMP signaling
      • Inositol triphosphate receptor
      • Biochemicals
      • Research Area
      • Cancer
      • Signal transduction
      • Inositol & cAMP signaling
      • Inositol triphosphate receptor
      • Biochemicals
      • Research Area
      • Cancer
      • Ca2+ signaling
      • IP3 & ryanodine receptors

    Images

    • Chemical Structure - Xestospongin C, IP<sub>3</sub> receptor antagonist (ab120914)
      Chemical Structure - Xestospongin C, IP3 receptor antagonist (ab120914)
      2D chemical structure image of ab120914, Xestospongin C, IP3 receptor antagonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (11)

    Publishing research using ab120914? Please let us know so that we can cite the reference in this datasheet.

    ab120914 has been referenced in 11 publications.

    • Malek M  et al. Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3. J Biol Chem 298:101740 (2022). PubMed: 35182526
    • Dulloo I  et al. iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2. Nat Commun 13:1257 (2022). PubMed: 35273168
    • Wang J  et al. Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3. Biochem Pharmacol 174:113832 (2020). PubMed: 32006470
    • Gupta K  et al. Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel. Biomaterials 259:120283 (2020). PubMed: 32827796
    • Luo R  et al. Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats. FEBS J 286:4356-4373 (2019). PubMed: 31230413
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    Can you tell me if your product is in clear glass or amber vials?

    Read More

    Abcam community

    Verified customer

    Asked on Jan 16 2014

    Answer

    We have some inventory of Xestospongin C in clear glass. We are currently in the process of changing from clear glass vials to amber vials for this product. Supplying Xestospongin C in amber vials is a precautionary measure as it appears that Xestospongin C’s sensitivity to light is based on long term studies (6+ months of exposure to direct light). Since the product is intended to be kept at – 20 C for long term storage primarily it will be in the freezer where it is dark, the customer could shield the vial from light when it is outside of the freezer if it is in a clear vial.

    Read More

    達偉 鄭

    Abcam Scientific Support

    Answered on Jan 16 2014

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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