Product nameAnti-XPF antibody
See all XPF primary antibodies
DescriptionRabbit polyclonal to XPF
Tested applicationsSuitable for: WB, ELISA, IPmore details
Species reactivityReacts with: Mouse, Human
Synthetic peptide derived from an internal sequence of human XPF.
- Extracts from 293 cells.
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.87% Sodium chloride, 50% Glycerol, PBS
Without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab73720 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 103 kDa.|
|IP||Use at an assay dependent concentration. PubMed: 24726326|
FunctionStructure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
Involvement in diseaseDefects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F) [MIM:278760]; also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities.
Defects in ERCC4 are a cause of XFE progeroid syndrome (XFEPS) [MIM:610965]. This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly.
Sequence similaritiesBelongs to the XPF family.
Contains 1 ERCC4 domain.
- Information by UniProt
- DNA excision repair protein ERCC 4 antibody
- DNA excision repair protein ERCC-4 antibody
- DNA excision repair protein ERCC4 antibody
This product has been referenced in:
- Abdullah UB et al. RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks. EMBO J 36:2047-2060 (2017). WB . Read more (PubMed: 28607004) »
- Hodskinson MR et al. Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. Mol Cell 54:472-84 (2014). WB, IP ; Mouse . Read more (PubMed: 24726326) »