Key features and details
- Rabbit polyclonal to XPNPEP3
- Suitable for: IHC-P, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-XPNPEP3 antibody
See all XPNPEP3 primary antibodies
DescriptionRabbit polyclonal to XPNPEP3
Tested applicationsSuitable for: IHC-P, ICC/IF, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Rat, Cow
Recombinant fragment within Human XPNPEP3 aa 12-507. The exact sequence is proprietary. NP_071381.1
Database link: Q9NQH7
- Human kidney tissue; A549 cells; A431 whole cell lysate.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 89% Tris glycine
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab192826 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 7.5 µg/ml.|
|ICC/IF||1/100 - 1/1000.|
|WB||1/500 - 1/3000. Predicted molecular weight: 57 kDa.|
Tissue specificityIsoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.
Involvement in diseaseDefects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 (NPHPL1) [MIM:613159]. A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. In NPHPL1 patients, extrarenal symptoms include hypertension, essential tremor, sensorineural hearing loss and gout. Severely affected individuals can manifest a mitochondrial disorder with isolated complex I deficiency activity in muscle, seizures, mental retardation and hypertrophic dilated cardiomyopathy.
Sequence similaritiesBelongs to the peptidase M24B family.
- Information by UniProt
- Aminopeptidase P3 antibody
- APP3 antibody
- NPHPL1 antibody
Immunohistochemical analysis of formalin fixed, paraffin embedded Human kidney tissue labeling XPNPEP3 with ab192826 at 7.5 µg/ml.
Anti-XPNPEP3 antibody (ab192826) at 1/500 dilution + A431 whole cell lysate at 30 µg
Predicted band size: 57 kDa
7.5% SDS PAGE
ab192896 (1:200 dilution) staining XPNPEP3 in paraformaldehyde-fixed A549 by ICC/IF (Immunocytochemistry/Immunofluorescence).
ab192826 has not yet been referenced specifically in any publications.