Product nameAnti-XRCC1 (phospho S485 + T488) antibody
See all XRCC1 primary antibodies
DescriptionRabbit polyclonal to XRCC1 (phospho S485 + T488)
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese hamster, Orangutan
Synthetic peptide to a region surrounding residues Ser 485 and Thr 488 of Human XRCC1, Swiss Prot P18887.
- Human breast adenocarcinoma. Mouse squamous cell carcinoma.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration information loading...
PurityImmunogen affinity purified
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Purine and pyrimidine synthesis
Our Abpromise guarantee covers the use of ab84418 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionCorrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Sequence similaritiesContains 2 BRCT domains.
modificationsPhosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Cellular localizationNucleus. Accumulates at sites of DNA damage.
- Information by UniProt
- DNA repair protein XRCC1 antibody
- RCC antibody
- X ray repair complementing defective repair in chinese hamster antibody
Detection of Human XRCC1 (phospho S485 + T488) by Immunohistochemistry.
Samples: FFPE serial sections of Human breast adenocarcinoma. Mock phosphatase treated section (left) or calf intestinal phosphatase-treated section (right) immunostained for XRCC1 (phospho S485 + T488).Antibody: ab84418 used at a dilution of 1/250.
Detection: DAB staining.
Detection of Mouse XRCC1 (phospho S485 + T488) by Immunohistochemistry.
Sample: FFPE section of Mouse squamous cell carcinoma.Antibody: ab84418 used at a dilution of 1/250.
ab84418 has not yet been referenced specifically in any publications.