Overview

  • Product name

    Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor
  • Description

    Selective Rho kinase inhibitor. 1 ml water soluble pack.
  • Biological description

    Selective Rho kinase inhibitor.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
  • Purity

    > 99%
  • CAS Number

    129830-38-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride
  • Molecular weight

    320.26
  • Molecular formula

    C14H21N3O.2HCl
  • PubChem identifier

    9901617
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 of ml water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Cl.O=C(Nc1ccncc1)[C@@H]2CC[C@H](CC2)[C@@H](C)N
  • Source

    Synthetic

  • Research areas

Images

  • Representative morphology and membrane potential responses to current step injection in hESMNs at 3 different times in vitro.

    Imaging of cells fixed after patch-clamp recordings indicate that recorded cells express the Hb9::GFP reporter transgene (A-C,E,G,and I). Voltage responses and imaging in the same rows are taken from same neurons. The neurons for A-C are same as that shown in F and G. D,F,H show examples of voltage responses to current steps recorded from 3 neurons current-clamped at −58 mV, −60 mV, and −55 mV, respectively. Bottom traces in D,F, and H show injected currents. Scale bars in images are 50 μm.

    Only part of full image panel shown.

    Cells were pre-treated with ab144494.

References

ab144494 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

What we were trying to say iss that this product is intended to be reconstituted with 1 ml of water to make a 20mM concentration.

Indeed we also sell this product in mg under reference number Y-27632 dihydrochloride (ab120129). In this format, it is up to the customer to weight out the product and calculate how much water to add to get the desired concentration.

With our new pack sizes, ab144494 has already been weighed out to give you a 20mM solution upon the addition of 1 ml of water so you do not need to do the calculations yourself and it is easier and quicker to prepare.

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up