Overview

  • Product name

    Yangonin, NF-kappabeta inhibitor
  • Description

    Potent NF-κβ inhibitor. Selective CB1 agonist. Antioxidant.
  • Biological description

    Potent NF-κβ inhibitor. Selective CB1 agonist. (Ki values are 0.7 and 10 μM for CB1 and CB2 respectively). Shows potent antioxidant effects. Active in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    500-62-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ma J  et al. Yangonin blocks tumor necrosis factor-a-induced nuclear factor-?B-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci 118:447-54 (2012). Read more (PubMed: 22510965) »
  • Ligresti A  et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB1 receptor ligand. Pharmacol Res 66:163-9 (2012). Read more (PubMed: 22525682) »
  • Xia Q  et al. Phototoxicity of kava - formation of reactive oxygen species leading to lipid peroxidation and DNA damage. Am J Chin Med 40:1271-88 (2012). Read more (PubMed: 23227797) »

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