Product nameYangonin, NF-kappabeta inhibitor
DescriptionPotent NF-κβ inhibitor. Selective CB1 agonist. Antioxidant.
Biological descriptionPotent NF-κβ inhibitor. Selective CB1 agonist. (Ki values are 0.7 and 10 μM for CB1 and CB2 respectively). Shows potent antioxidant effects. Active in vivo. Orally active.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol (with heating)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- Nitric oxide & oxidative stress
This product has been referenced in:
- Ma J et al. Yangonin blocks tumor necrosis factor-a-induced nuclear factor-?B-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci 118:447-54 (2012). Read more (PubMed: 22510965) »
- Ligresti A et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB1 receptor ligand. Pharmacol Res 66:163-9 (2012). Read more (PubMed: 22525682) »
- Xia Q et al. Phototoxicity of kava - formation of reactive oxygen species leading to lipid peroxidation and DNA damage. Am J Chin Med 40:1271-88 (2012). Read more (PubMed: 23227797) »