Overview

  • Product name

  • Description

    Rabbit polyclonal to YARS2/TyRS
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human YARS2/TyRS (internal sequence). The exact sequence is proprietary.
    Database link: Q9Y2Z4

  • Positive control

    • IHC-P: Human colon carcinoma tissue. WB: NTERA-2 cl.D1 [NT2/D1] whole cell lysate.
  • General notes

    Protein previously labeled as YARS2.

Properties

Applications

Our Abpromise guarantee covers the use of ab228957 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 53 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
  • Involvement in disease

    Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2) [MIM:613561]. MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia.
  • Sequence similarities

    Belongs to the class-I aminoacyl-tRNA synthetase family.
  • Cellular localization

    Mitochondrion matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • CGI 04 antibody
    • FLJ13995 antibody
    • mitochondrial antibody
    • MLASA2 antibody
    • mt TyrRS antibody
    • SYYM_HUMAN antibody
    • Tyrosine tRNA ligase 2 mitochondrial antibody
    • Tyrosine tRNA ligase antibody
    • Tyrosine tRNA ligase mitochondrial antibody
    • Tyrosine--tRNA ligase antibody
    • Tyrosyl tRNA synthetase 2 mitochondrial antibody
    • Tyrosyl tRNA synthetase mitochondrial precursor antibody
    • Tyrosyl-tRNA synthetase antibody
    • TyrRS antibody
    • YARS 2 antibody
    • YARS2 antibody
    see all

Images

  • Paraffin-embedded human colon carcinoma tissue stained for YARS2/TyrRS using ab228957 at 1/250 dilution in immunohistochemical analysis.

  • Anti-YARS2/TyRS antibody (ab228957) at 1/1000 dilution + NTERA-2 cl.D1 [NT2/D1] (human malignant pluripotent embryonic carcinoma cell line) whole cell lysate at 30 µg

    Predicted band size: 53 kDa



    10% SDS PAGE gel.

References

ab228957 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab228957.
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