Overview

  • Product name

    YC-1, guanylyl cyclase activator
  • Description

    Reversible soluble guanylyl cyclase activator
  • Biological description

    Reversible soluble guanylyl cyclase activator (EC50 = 18.6 μM). NO-independent. Induces a concentration dependent increase in cGMP in vitro. Reduces blood-brain barrier permeability through HIF-1 inhibiton in vivo.
  • Purity

    > 99%
  • CAS Number

    170632-47-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[1-(Phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
  • Molecular weight

    304.35
  • Molecular formula

    C19H16N2O2
  • PubChem identifier

    5712
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Yan J  et al. Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke. PLoS One 6:e27798 (2011). Read more (PubMed: 22110762) »
  • Pal B & Kitagawa T Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation. Biochem Biophys Res Commun 397:375-9 (2010). Read more (PubMed: 20513359) »
  • Mülsch A  et al. Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. Br J Pharmacol 120:681-9 (1997). Read more (PubMed: 9051308) »

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