Overview

  • Product name

    Anti-YKL-40/CHI3L1 antibody
    See all YKL-40/CHI3L1 primary antibodies
  • Description

    Rabbit polyclonal to YKL-40/CHI3L1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Pig, Orangutan
  • Immunogen

    Recombinant full length protein corresponding to Human YKL-40/CHI3L1 aa 1-383.
    Sequence:

    MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALDRFL CTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWN FGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHF TTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDF ISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAP ASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEIC DFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAM VWALDLDDFQGSFCGQDLRFPLTNAIKDALAAT


    Database link: P36222

  • Positive control

    • TPH1 cell extracts.
  • General notes

    Previously labelled as CHI3L1

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab180569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 43 kDa.
IHC-P 1/50 - 1/100.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

Target

  • Function

    Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.
  • Tissue specificity

    Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.
  • Involvement in disease

    A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
  • Sequence similarities

    Belongs to the glycosyl hydrolase 18 family.
  • Post-translational
    modifications

    Glycosylated.
  • Cellular localization

    Secreted > extracellular space.
  • Information by UniProt
  • Database links

  • Alternative names

    • 39 kDa synovial protein antibody
    • ASRT7 antibody
    • Cartilage glycoprotein 39 antibody
    • CGP-39 antibody
    • CGP39 antibody
    • CH3L1_HUMAN antibody
    • CHI3L1 antibody
    • chitinase 3 like 1 (cartilage glycoprotein 39) antibody
    • chitinase 3 like 1 antibody
    • Chitinase 3 like protein 1 precursor antibody
    • chitinase antibody
    • Chitinase-3-like protein 1 antibody
    • Chondrocyte protein YKL40 antibody
    • GP 39 antibody
    • GP-39 antibody
    • GP39 antibody
    • HC gp39 antibody
    • HCGP 3P antibody
    • hCGP-39 antibody
    • HCgp39 antibody
    • YKL 40 antibody
    • YKL-40 antibody
    • YKL40 antibody
    • YYL 40 antibody
    see all

Images

  • Anti-YKL-40/CHI3L1 antibody (ab180569) at 1/500 dilution + THP-1 cell lysate

    Predicted band size: 43 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thyroid cancer tissue labelling YKL-40/CHI3L1 with ab180569 at a dilution of 1/50.

References

This product has been referenced in:

  • Chen C  et al. FOXO1 associated with sensitivity to chemotherapy drugs and glial-mesenchymal transition in glioma. J Cell Biochem 120:882-893 (2019). Read more (PubMed: 30216501) »
See 1 Publication for this product

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