Overview

  • Product name

    YM-155, survivin inhibitor
  • Description

    Novel small molecule survivin inhibitor
  • Alternative names

    • Sepantronium bromide
    • YM155
  • Purity

    > 98%
  • CAS Number

    781661-94-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide

  • Molecular weight

    443.29
  • Molecular formula

    C20H19BrN4O3
  • PubChem identifier

    11178236
  • Storage instructions

    Shipped at room temperature. Store at -20°C.
  • Solubility overview

    Soluble in DMSO to 55 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
  • Source

    Synthetic

References

This product has been referenced in:

  • Wang YF  et al. Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma. Apoptosis 19:748-58 (2014). Read more (PubMed: 24370995) »
  • Okamoto K  et al. Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin. Mol Cancer Ther 11:204-13 (2012). Read more (PubMed: 22075159) »
  • Glaros TG  et al. The "survivin suppressants" NSC 80467 and YM155 induce a DNA damage response. Cancer Chemother Pharmacol 70:207-12 (2012). Read more (PubMed: 22526412) »
  • Nakahara T  et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res 67:8014-21 (2007). Read more (PubMed: 17804712) »

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