Product nameYM-155, survivin inhibitor
DescriptionNovel small molecule survivin inhibitor
- Sepantronium bromide
Storage instructionsShipped at room temperature. Store at -20°C.
Soluble in DMSO to 55 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Wang YF et al. Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma. Apoptosis 19:748-58 (2014). Read more (PubMed: 24370995) »
- Okamoto K et al. Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin. Mol Cancer Ther 11:204-13 (2012). Read more (PubMed: 22075159) »
- Glaros TG et al. The "survivin suppressants" NSC 80467 and YM155 induce a DNA damage response. Cancer Chemother Pharmacol 70:207-12 (2012). Read more (PubMed: 22526412) »
- Nakahara T et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res 67:8014-21 (2007). Read more (PubMed: 17804712) »