YM-58483 (CRAC Channel Inhibitor, BTP2), CRAC channel inhibitor (ab144413)

Overview

  • Product name
    YM-58483 (CRAC Channel Inhibitor, BTP2), CRAC channel inhibitor
  • Description
    Store-operated Ca2+ entry blocker. Potent, selective CRAC channel inhibitor.
  • Alternative names
    • CRAC Channel Inhibitor, BTP2
  • Biological description
    Store-operated Ca2+ entry blocker. Potent, selective CRAC channel inhibitor. Inhibits thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Suppresses cytokine production. Potent T-cell antiproliferative agent (IC50 = 12.7 nM). Shows immunomodulatory and anti-inflammatory effects in vivo. Orally active.
  • Purity
    > 98%

Properties

  • Chemical name
    N-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
  • Molecular weight
    421.32
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C15H9F6N5OS
  • CAS Number
    223499-30-7
  • PubChem identifier
    2455
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Ohga K  et al. Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo. Int Immunopharmacol 8:1787-92 (2008). Read more (PubMed: 18793756) »
  • Yoshino T  et al. YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models. Eur J Pharmacol 560:225-33 (2007). Read more (PubMed: 17307161) »
  • Ishikawa J  et al. A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes. J Immunol 170:4441-9 (2003). Read more (PubMed: 12707319) »
See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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