Overview

  • Product name

    YM201636, PIKfyve inhibitor
  • Description

    Potent, selective, cell-permeable PIKfyve inhibitor
  • Biological description

    Potent, selective, cell-permeable PIKfyve inhibitor (IC50 = 33 nM). Reversibly inhibits endosomal trafficking. Inhibits basal and insulin-activated 2-deoxyglucose uptake (IC50 = 54 nM). Reduces cancer cell velocity.
  • Purity

    > 95%
  • CAS Number

    371942-69-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Oppelt A  et al. PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. Biochem J 461:383-90 (2014). Read more (PubMed: 24840251) »
  • Liu Y  et al. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle. Biochem J 455:195-206 (2013). Read more (PubMed: 23905686) »
  • Hazeki K  et al. PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses. PLoS One 8:e73894 (2013). Read more (PubMed: 24040108) »
See 1 Publication for this product

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