Overview

  • Product name

  • Description

    Rabbit polyclonal to YME1L1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human YME1L1 aa 1-240.
    Database link: Q96TA2

  • Positive control

    • WB: A549, jurkat, A431, HeLa, HepG2 and MCF7 cell lysates. IHC-P: Human tonsil and colon cancer tissues.
  • General notes

    Previously labelled as ATP-dependent metalloprotease YME1L1. 

Properties

Applications

Our Abpromise guarantee covers the use of ab234744 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
WB 1/1000 - 1/5000. Detects a band of approximately 87 kDa (predicted molecular weight: 86 kDa).

Target

  • Function

    Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1.
  • Tissue specificity

    High expression in cardiac and skeletal muscle mitochondria.
  • Sequence similarities

    In the N-terminal section; belongs to the AAA ATPase family.
    In the C-terminal section; belongs to the peptidase M41 family.
  • Cellular localization

    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ATP dependent metalloprotease FtsH1 homolog antibody
    • ATP-dependent metalloprotease FtsH1 antibody
    • ATP-dependent metalloprotease YME1L1 antibody
    • ATP-dependent zinc metalloprotease YME1L1 antibody
    • FTSH1 antibody
    • Meg-4 antibody
    • MEG4 antibody
    • PAMP antibody
    • Presenilin-associated metalloprotease antibody
    • UNQ1868/PRO4304 antibody
    • YME1 like 1 antibody
    • YME1-like protein 1 antibody
    • YME1L antibody
    • Yme1l1 antibody
    • YMEL1_HUMAN antibody
    see all

Images

  • All lanes : Anti-YME1L1 antibody (ab234744) at 1/1000 dilution

    Lane 1 : A549 (human lung carcinoma cell line) whole cell lysate
    Lane 2 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate
    Lane 3 : A431 (human epidermoid carcinoma cell line) whole cell lysate
    Lane 4 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
    Lane 5 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate
    Lane 6 : MCF7 (human breast adenocarcinoma cell line) whole cell lysate

    Secondary
    All lanes : Goat polyclonal to rabbit IgG at 1/10000 dilution

    Predicted band size: 86 kDa
    Observed band size: 87 kDa
    why is the actual band size different from the predicted?

  • Paraffin-embedded human tonsil tissue stained for YME1L1 using ab234744 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human colon cancer tissue stained for YME1L1 using ab234744 at 1/100 dilution in immunohistochemical analysis.

References

ab234744 has not yet been referenced specifically in any publications.

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