Overview

  • Product name

    YZ9, PFKFB3 inhibitor
  • Description

    PFKFB3 inhibitor
  • Biological description

    PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 0.18 µM). Competitively inhibits Fru-6-P (Ki = 94 nM). Inhibits cell growth (GI50 = 2.7 µM) in a XTT-based in vitro toxicology assay.
  • Purity

    > 99%
  • CAS Number

    6093-71-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-Hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester
  • Molecular weight

    234.21
  • Molecular formula

    C12H10O5
  • PubChem identifier

    5289613
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(OCC)C1=Cc2ccc(O)cc2OC1=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Seo M  et al. Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6:e24179 (2011). Read more (PubMed: 21957443) »

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