Overview

  • Product name

    Z-AEVD-FMK, caspase-10 and related caspases inhibitor 
  • Description

    Irreversible inhibitor of caspase-10 and related caspases
  • Biological description

    Irreversible inhibitor of caspase-10 (Ki = 320 nM) and related caspases. Inhibits FasL- and pyrimethamine-induced apoptosis. Cell-permeable. Active in vivo.
  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Milhas D  et al. Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. J Biol Chem 280:19836-42 (2005). Read more (PubMed: 15772077) »
  • Pierdominici M  et al. Pyrimethamine (2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine) induces apoptosis of freshly isolated human T lymphocytes, bypassing CD95/Fas molecule but involving its intrinsic pathway. J Pharmacol Exp Ther 315:1046-57 (2005). Read more (PubMed: 16157660) »
  • Garcia-Calvo M  et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 273:32608-13 (1998). Read more (PubMed: 9829999) »

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