Key features and details
- Irreversible inhibitor of caspase-10 and related caspases
- CAS Number:
- Purity: > 95%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Product nameZ-AEVD-FMK, caspase-10 and related caspases inhibitor
DescriptionIrreversible inhibitor of caspase-10 and related caspases
Biological descriptionIrreversible inhibitor of caspase-10 (Ki = 320 nM) and related caspases. Inhibits FasL- and pyrimethamine-induced apoptosis. Cell-permeable. Active in vivo.
SequenceAEVD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe))
Storage instructionsStore at -20°C (desiccating conditions).
Solubility overviewSupplied in DMSO (10 mM)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142028 has not yet been referenced specifically in any publications.