Overview

  • Product name

    Z-Asp-CH2-DCB, caspase inhibitor
  • Description

    Irreversible, cell permeable broad-spectrum caspase inhibitor
  • Biological description

    Irreversible, cell permeable broad-spectrum caspase inhibitor (IC50 values are 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively). Inhibits hypoxia-induced apoptosis. Shows anti-ischemic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    153088-73-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S)-5-(2,6-dichlorobenzoyl)oxy-4-oxo-3-(phenylmethoxycarbonylamino)pentanoic acid
  • Molecular weight

    454.26
  • Molecular formula

    C20H17Cl2NO7
  • PubChem identifier

    9911778
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)COC(=O)NC(CC(=O)O)C(=O)COC(=O)C2=C(C=CC=C2Cl)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sawai H Differential effects of caspase inhibitors on TNF-induced necroptosis. Biochem Biophys Res Commun 432:451-5 (2013). Read more (PubMed: 23410748) »
  • Twumasi P  et al. Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures. BMC Plant Biol 10:162 (2010). Read more (PubMed: 20691058) »
  • Drognitz O  et al. Effects of organ preservation, ischemia time and caspase inhibition on apoptosis and microcirculation in rat pancreas transplantation. Am J Transplant 4:1042-50 (2004). Read more (PubMed: 15196060) »

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