Biological descriptionSpecific caspase-12 inhibitor. Suppresses annular cell apoptosis and caspase-9 activity in vitro. Active in vitro and in vivo.
SequenceATAD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Asp-4 = Asp(OMe))
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 20 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Research Area
- Alzheimer's Disease
- Signal transduction
- Hedgehog signaling
This product has been referenced in:
- Zhang YH et al. Cyclic stretch-induced apoptosis in rat annulus fibrosus cells is mediated in part by endoplasmic reticulum stress through nitric oxide production. Eur Spine J 20:1233-43 (2011). Read more (PubMed: 21336971) »
- Zhao CQ et al. Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats. Age (Dordr) 32:161-77 (2010). Read more (PubMed: 19960285) »
- Kim SM et al. Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL. Toxicol Appl Pharmacol 241:210-20 (2009). Read more (PubMed: 19716835) »