Overview

  • Product name

    Z-FA-FMK, Cysteine protease inhibitor
  • Description

    Irreversible cysteine protease inhibitor. Cell-permeable caspase effector inhibitor.
  • Biological description

    Irreversible cysteine protease inhibitor. Cell-permeable caspase effector inhibitor. Selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Inhibits cathepsin B, L, and S, papain and cruzain. Induces apoptosis and necrosis. Shows anti-inflammatory effects in vivo.
  • Purity

    > 95%
  • CAS Number

    105637-38-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Liow KY & Chow SC The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes. Toxicol Appl Pharmacol 272:559-67 (2013). Read more (PubMed: 23933532) »
  • Lopez-Hernandez FJ  et al. Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway. Mol Cancer Ther 2:255-63 (2003). Read more (PubMed: 12657720) »
See 1 Publication for this product

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