Key features and details
- Irreversible cysteine protease inhibitor. Cell-permeable caspase effector inhibitor.
- CAS Number: 105637-38-5
- Purity: > 95%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameZ-FA-FMK, Cysteine protease inhibitor
DescriptionIrreversible cysteine protease inhibitor. Cell-permeable caspase effector inhibitor.
Irreversible cysteine protease inhibitor. Cell-permeable caspase effector inhibitor. Selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Inhibits cathepsin B, L, and S, papain and cruzain. Induces apoptosis and necrosis. Shows anti-inflammatory effects in vivo. Negative control for caspase inhibitors. Liquid form also available (ab141384)
Chemical nameBenzyl N-[1-[(4-fluoro-3-oxobutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141484 has been referenced in 2 publications.
- Koike S et al. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. Int J Mol Sci 17:N/A (2016). PubMed: 27649164
- Harrison JS et al. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts. Oncotarget 7:36447-36460 (2016). PubMed: 27144333